What are the characteristics of an ideal blood substitute?

Updated: Dec 11, 2018
  • Author: Sara J Grethlein, MD; Chief Editor: Emmanuel C Besa, MD  more...
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The most important adverse effects of blood transfusion relate to the antigenicity of donor blood and its ability to transmit infections. Hence, an ideal blood substitute should lack antigenicity and eliminate, or at least substantially reduce, the ability to transmit infections. In addition, it should be readily available, should have a long half-life, and should be capable of being stored at room temperature. The biologic properties of an ideal blood substitute should include a reasonable amount of oxygen delivery, when compared to normal human red blood cells. [3]

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