What are the National Comprehensive Cancer Network (NCCN) recommendations for the initial workup for acute lymphoblastic leukemia (ALL)?

Updated: Feb 20, 2020
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print

NCCN recommendations for the initial workup include the following:

  • History and physical
  • CBC, platelets, differential
  • Chemistry profile
  • Disseminated intravascular coagulation (DIC) panel
  • Tumor lysis syndrome panel
  • Computed tomography/magnetic resonance imaging (CT/MRI) of head with contrast, if neurologic symptoms
  • Lumbar puncture
  • CT of chest with contrast (for patients with T-ALL), plus baseline positron emission tomography (PET) imaging for patients with a mediastinal mass
  • Testicular exam
  • Infection evaluation: Screen for active infections if febrile or for symptomatic opportunistic infections
  • Consider echocardiogram or cardiac scan, especially in patients with prior cardiac history and prior anthracycline exposure or clinical symptoms suggestive of cardiac dysfunction.
  • Central venous access device of choice
  • Human leukocyte antigen (HLA) typing (except for patients with a major contraindication to hematopoietic cell transplant)

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!