What are common prophylactic antibiotic regimens used in the treatment of acute lymphoblastic leukemia (ALL)?

Updated: Oct 26, 2020
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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The use of prophylactic antibiotics in neutropenic patients who are not febrile is controversial. However, most clinicians prescribe them for patients undergoing induction therapy. A commonly used regimen includes the following:

  • Ciprofloxacin (oral [PO] 500 mg twice daily [bid])

  • Fluconazole (200 mg PO daily), voriconazole (200 mg PO bid), or posaconazole (200 mg PO three times daily [tid])

  • Acyclovir (200 mg PO 5 times/d) or valacyclovir (500 mg PO daily)

Once patients taking these antibiotics become febrile, they are switched to intravenous antibiotics.

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