How is gene therapy used to treat acute lymphoblastic leukemia (ALL)?

Updated: Jun 20, 2019
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Chimeric antigen receptor (CAR) T-cell therapy is a treatment in which the patient's own T-cells are collected from peripheral blood and genetically engineered to express a CAR that targets a specific molecule on the cancer cells. The modified T-cells are then expanded and reinfused into the patient, after lymphodepletion with conditioning chemotherapy. [79]


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