What is the efficacy of unrelated-donor (URD) transplantation for the treatment of acute lymphoblastic leukemia (ALL)?

Updated: Jul 17, 2018
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

For patients without a sibling donor, an alternative is an unrelated-donor (URD) transplant. Weisdorf et al found that autologous BMT was associated with a lower transplant-related mortality rate, but URD transplantations had a lower risk of relapse. [64] In patients whose disease was in second CR, URD transplantations resulted in a superior rate of disease-free survival. [64]


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