What are survival rates of acute lymphoblastic leukemia (ALL) following allogeneic bone marrow transplantation (BMT)?

Updated: Jul 17, 2018
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Answer

In a prospective, nonrandomized trial, the Bordeaux, Grenoble, Marseille, Toulouse group found that the 3-year probability of disease-free survival was significantly higher with allogeneic BMT (68%) than with autologous BMT (26%). [60] No benefit was observed with the addition of recombinant interleukin 2 (IL-2) after autologous BMT.

In the French Group on Therapy for Adult Acute Lymphoblastic Leukemia study, subjects aged 15-40 years whose disease was in CR and who had a human leukocyte antigen (HLA)-compatible sibling donor underwent allogeneic BMT. [61] The other subjects were randomized to receive autologous BMT or chemotherapy. Overall, no difference in was observed in 5-year survival between the groups. [61]

However, when only high-risk patients were considered (ie, Ph+, null ALL; >35 y; white blood cell [WBC] count >30,000/µL; or time to CR >4 wk), allogeneic BMT proved superior to autologous BMT or chemotherapy with respect to overall survival rates (44% vs 20%) and disease-free survival rates (39% vs 14%). [61] Other phase 2 studies have confirmed a benefit for high-risk patients who undergo allogeneic BMT, with as many as 50% achieving long-term remissions.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!