What is the prognosis of with acute lymphoblastic leukemia (ALL) in older children and young adults?

Updated: Jun 20, 2019
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Stock et al performed a retrospective comparison of presenting features, planned treatment, complete remission (CR) rate, and outcome in 321 adolescents and young adults (AYAs) ages 16 to 20 years with newly diagnosed ALL who were treated in consecutive trials in either the Children's Cancer Group (CCG) or the Cancer and Leukemia Group B (CALGB) from 1988 to 2001. CR rates were identical, 90% for both CALGB and CCG AYAs. CCG AYAs had a 63% event-free survival (EFS) and 67% overall survival at 7 years in contrast to the CALGB AYAs, in which 7-year EFS was only 34% (P < 0.001) and OS was 46% (P < 0.001) [59] .


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