How is Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL) treated?

Updated: Jun 20, 2019
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

In the past, Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL) was treated with the same regimens as other types of ALL, with poor results. However, tyrosine kinase inhibitors that inhibit the bcr-abl fusion protein of Ph+ ALL allow targeted therapy of this disease.


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