What is the prevalence of cytogenetic abnormalities in acute lymphoblastic leukemia (ALL)?

Updated: Jun 20, 2019
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Cytogenetic abnormalities occur in approximately 70% of cases of ALL in adults (see Table 2, below). These abnormalities include balanced translocations as occur in cases of AML. However, abnormalities of chromosome number (hypodiploidy, hyperdiploidy) are more common in ALL than in AML.

Table 2. Common Cytogenetic Abnormalities in ALL (Open Table in a new window)

Abnormality

Genes Involved

3-Year Event-Free Survival

t(10;14)(q24;q11)

HOX11/TCRA

75%

6q

Unknown

47%

14q11

TCRA/TCRD

42%

11q23

MLL

18-26%

9p

Unknown

22%

12

TEL

20%

t(1;19)(q23;p13)

PBX1/E2A

20%

t(8;14)(q24;q32)

t(2;8)(p12;q24)

t(8;22)(q24;q11)

c-myc/IGH

IGK/c-myc

c-myc/IGL

17%*

80%

t(9;22)(q34;q11)

bcr-abl

5-10%*

66%

t(4;11)(q21;q23)

AF4-MLL

0-10%

* Traditional regimens.

 Hyper-CVAD (cyclophosphamide, vincristine, doxorubicin [Adriamycin], dexamethasone) with rituxan.

 Hyper-CVAD with imatinib.


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