What are the National Comprehensive Cancer Network (NCCN) criteria for diagnosis of acute lymphoblastic leukemia (ALL)?

Updated: Oct 26, 2020
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print

National Comprehensive Cancer Network (NCCN) guidelines note that diagnosis of ALL generally requires the following [20] :

  • Demonstration of ≥20% bone marrow lymphoblasts
  • Morphologic assessment of Wright/Giemsa–stained bone marrow aspirate smears
  • Hematoxylin and eosin (H&E)–stained bone marrow core biopsy and clot sections
  • Comprehensive flow cytometric immunophenotyping
  • Baseline characterization of the leukemic clone, to facilitate subsequent minimal residual disease (MRD) analysis

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!