Which tests and studies are performed in the evaluation of acute lymphoblastic leukemia (ALL)?

Updated: Jun 20, 2019
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Laboratory tests and other studies used in the workup for ALL include the following:

  • Complete blood count with differential

  • Coagulation studies, including PT, PTT, fibrinogen and fibrin split products

  • Peripheral blood smear

  • Chemistry profile, including lactic dehydrogenase, uric acid, liver function studies, and BUN/creatinine

  • Appropriate cultures (in particular, blood cultures) in patients with fever or other signs of infection

  • Chest x-ray

  • Computed tomography, as indicated by symptoms

  • Multiple-gated acquisition scanning or echocardiogram

  • Electrocardiography

  • Lumbar puncture

  • Bone marrow aspiration and biopsy (definitive for confirming leukemia)

Bone marrow studies include the following:

  • Histology
  • Immunohistochemistry/flow cytometry
  • Cytogenetics
  • Fluorescence in situ hybridization
  • Polymerase chain reaction
  • Next-generation sequencing

See Workup for more detail.

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