Which tests and studies are performed in the evaluation of acute lymphoblastic leukemia (ALL)?

Updated: Jul 17, 2018
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Laboratory tests and other studies used in the workup for ALL include the following:

  • Complete blood count with differential

  • Coagulation studies, including PT, PTT, fibrinogen and fibrin split products

  • Peripheral blood smear

  • Chemistry profile, including lactic dehydrogenase, uric acid, liver function studies, and BUN/creatinine

  • Appropriate cultures (in particular, blood cultures) in patients with fever or other signs of infection

  • Chest x-ray

  • Computed tomography, as indicated by symptoms

  • Multiple-gated acquisition scanning or echocardiogram

  • Electrocardiography

  • Bone marrow aspiration and biopsy (definitive for confirming leukemia)

    • Histology
    • Immunohistochemistry/flow cytometry
    • Cytogenetics

    • Fluorescence in situ hybridization

    • Polymerase chain reaction

    • Next generation sequencing

See Workup for more detail.


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