What are the signs and symptoms of acute lymphoblastic leukemia (ALL)?

Updated: Jul 17, 2018
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Signs and symptoms of ALL include the following:

  • Fever

  • Signs and symptoms of anemia, such as pallor, fatigue, dizziness, palpitations, cardiac flow murmur, and dyspnea with even mild exertion

  • Bleeding 

  • Disseminated intravascular coagulation (DIC) at diagnosis (about 10% of cases)

  • Blood clots

  • Palpable lymphadenopathy

  • Symptoms related to a large mediastinal mass (eg, shortness of breath), particularly with T-cell lymphoblastic leukemia/lymphoma (T-ALL)

  • Bone pain (can be severe and often atypical)

  • Left upper quadrant fullness and early satiety due to splenomegaly (about 10% of cases)

  • Symptoms of leukostasis (eg, respiratory distress, altered mental status)

  • Renal failure in patients with a high tumor burden

  • Infections, including pneumonia

  • Petechiae (particularly on lower extremities) and ecchymoses

  • Rashes from skin infiltration with leukemic cells

See Presentation for more detail.

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