Which drugs are used in the treatment of paroxysmal nocturnal hemoglobinuria (PNH)?

Updated: May 20, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

The agents used in treatment of paroxysmal nocturnal hemoglobinuria (PNH) include the following:

  • Complement inhibitors (eg, pegcetacoplan, eculizumab, ravulizumab), to stop hemolysis
  • Recombinant erythropoietin or androgens, to stimulate erythropoiesis
  • Anticoagulants, to treat thrombotic complications
  • Immunosuppressive agents, to stimulate hematopoiesis in the aplastic phase

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