What is the risk of paroxysmal nocturnal hemoglobinuria (PNH) during pregnancy?

Updated: May 20, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

Pregnancy in patients with PNH poses very significant risks. There is a very high risk of thrombotic complications for the expectant mother, as well a risk of developing hypoplastic anemia. Maternal mortality in these patients is approximately 20%, mostly from thrombosis and infections, and risk of fetal loss is increased. Consequently, full anticoagulation with low-molecular weight heparin (LMWH) is recommended for pregnant women with PNH. Warfarin may be substituted after the first trimester.


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