How is paroxysmal nocturnal hemoglobinuria (PNH) diagnosed?

Updated: May 20, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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The principal studies used to establish the diagnosis of PNH are flow cytometry of peripheral blood and bone marrow analysis. Flow cytometry measures the percentage of cells with the deficiency in complement-regulating surface proteins that underlies PNH; bone marrow analysis differentiates classic PNH from PNH secondary to other bone marrow disorders. (See Workup ).

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