How are kidney complications of paroxysmal nocturnal hemoglobinuria (PNH) treated?

Updated: May 20, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

Chronic hemolysis and renal iron deposition, which is a particular risk in PNH when complement inhibition therapy is delayed or not available, may result in acute tubular injury or acute kidney injury (AKI). Consultation with a nephrologist may be indicated to help manage these cases. Continuous renal replacement therapy (CRRT) is one of the best options for the treatment of PNH-associated AKI. Dialysis techniques may include immunoadsorption, dedicated hemodialysis filters that use convective techniques, backfiltration, or coupled plasma filtration adsorption (CPFA). [36]


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