What is the role of a technetium-99m (99m Tc) colloid scan in the workup of paroxysmal nocturnal hemoglobinuria (PNH)?

Updated: May 20, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

Investigate hepatic vein thrombosis with a routine technetium-99m (99m Tc) colloid scan of the liver and spleen. This study often reveals diminished function in all portions of the liver except the caudate lobe, which is spared because it is drained by the inferior vena cava rather than the hepatic vein. A magnetic resonance imaging (MRI) study or ultrasonogram can demonstrate the cessation of flow through the hepatic vein or by injection or use of a dye to demonstrate a thrombus in the vein.


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