Which tests may be performed to demonstrate intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH)?

Updated: May 20, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Other tests to demonstrate intravascular hemolysis include the following:

  • Elevated serum lactate dehydrogenase (LDH)
  • Elevated reticulocyte count
  • Low-to-absent serum haptoglobin
  • Hemoglobinuria and hemosiderinuria; however, hemolysis may occur intermittently and hence can be missed easily, depending on when the tests are performed

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