What is the sensitivity of the flow cytometry test in the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH)?

Updated: May 20, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

Standard and high-sensitivity flow cytometric procedures for detecting PNH cells are now available. [25] For routine analysis and diagnosis of suspected PNH, the standard test is sufficient. This test can detect 1% or more PNH cells, bu; most laboratories report only 10% or more as a positive result. High-sensitivity analysis (in which as little as 0.01% PNH cells can be detected) may be helpful in aplastic anemia patients, who may eventually develop PNH, and possibly in those with hypoplastic myelodysplasia syndrome (MDS), to predict responses to immunosuppressive therapy.


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