What is the prevalence of severe aplastic anemia in paroxysmal nocturnal hemoglobinuria?

Updated: May 20, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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A review of 282 Korean patients with PNH by Kim et al identified 24 patients with both PNH and severe aplastic anemia (ie, with at least two of the following three criteria: hemoglobin ≤8 g/dL; absolute neutrophil count (ANC) < 0.5 × 109/L; platelet count < 20 × 109/L). Compared with patients with classic PNH, the patients with PNH and severe aplastic anemia had a significantly lower median granulocyte PNH clone size (26.7 vs. 51.0%, P = 0.021), a lower incidence of lactate dehydrogenase levels ≥1.5 times the upper limit of normal (52.9 vs. 80.0%, P = 0.049), and significantly lower survival. Given those differences, these authors suggest that identifying this subgroup at the time of diagnosis may be important. [23]

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