When should paroxysmal nocturnal hemoglobinuria (PNH) be suspected?

Updated: May 20, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

Patients should be tested at least once for paroxysmal nocturnal hemoglobinuria (PNH) if they have any of the following [22] :

  • Evidence of hemoglobinuria
  • Unexplained hemolysis (increased lactate dehydrogenase [LDH] level, absent haptoglobin)
  • Abdominal or cerebral vein thrombosis
  • hrombocytopenia, macrocytosis, or signs of hemolysis

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