What are the symptoms of paroxysmal nocturnal hemoglobinuria (PNH)?

Updated: May 20, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

Because NO regulates smooth muscle tone, depletion of NO levels leads to smooth muscle contraction with consequent vasoconstriction, constriction of the gut, and pulmonary hypertension. Resultant symptoms may include the following:

  • Abdominal pain
  • Bloating
  • Back pain
  • Headaches
  • Esophageal spasms
  • Erectile dysfunction
  • Fatigue

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