Which medications in the drug class Immunomodulators are used in the treatment of Myelodysplastic Syndrome?

Updated: Jul 24, 2018
  • Author: Emmanuel C Besa, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

Immunomodulators

Immunomodulators elicit immunomodulatory, antiangiogenic properties, and inhibit proinflammatory cytokines.

Lenalidomide (Revlimid)

Lenalidomide is indicated for the transfusion-dependent MDS subtype of deletion 5q cytogenetic abnormality. This agent is structurally similar to thalidomide. It elicits immunomodulatory and antiangiogenic properties, inhibits proinflammatory cytokine secretion, and increases release of anti-inflammatory cytokines from peripheral blood mononuclear cells. The dose used in MDS is much lower than that used for multiple myeloma.


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