What are the NCCN guidelines for supportive care for myelodysplastic syndrome (MDS)?

Updated: Jul 24, 2018
  • Author: Emmanuel C Besa, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

The NCCN guidelines recommend supportive care as the standard of care for patients with lower-risk MDS. Supportive care includes the following [24] :

  • Clinical monitoring, psychosocial support and quality of life assessment
  • Red blood cell (RBC) transfusions for symptomatic anemia
  • Platelet transfusions for thrombocytopenic bleeding; aminocaprioic acid may be considered for profound thrombocytopenia
  • Cytomegalovirus (CMV)-negative or leuko-reduced blood products for CMV-negative transplant candidates
  • No routine antibiotic prophylaxis except in patients with recurrent infections
  • Management of iron overload in patients who have received >20 to 30 RBC transfusions with deferoxamine subcutaneously or deferasirox orally, except in patients with low creatinine clearance (< 40 mL/min)

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