How is Lower-Risk Prognostic Scoring System (LR-PSS) calculated for myelodysplastic syndrome (MDS)?

Updated: Apr 10, 2020
  • Author: Emmanuel C Besa, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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In 2008, researchers at MD Anderson Cancer Center developed the Lower-Risk Prognostic Scoring System (LR-PSS) to identify patients with very low or low risk with a poorer prognosis. The model is a refinement of IPSS and included the following factors that were independent predictors of survival outcomes [53] :

  • Unfavorable cytogenetics
  • ≥60 years old
  • Decreased hemoglobin level
  • Decreased platelet count
  • Higher percentage of bone marrow blasts

Each factor was given a weighted score and based on the total, patients were assigned to one of the following risk categories:

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