How is the WHO Prognostic Scoring System (WPSS) calculated for myelodysplastic syndrome (MDS)?

Updated: Jul 24, 2018
  • Author: Emmanuel C Besa, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

The WHO Prognostic Scoring System (WPSS) was developed in 2005 based on the 2001 WHO classifications and refined most recently in 2011. [41, 42] In contrast to the IPSS and IPSS-R, which are applied only at the time of diagnosis, the WPSS is dynamic, and patients can be reassigned categories as their disease progresses. The WHO score is calculated on the basis of the following three factors [42]

  • WHO disorder classification (0-3)
  • Karyotype (0-2)
  • Presence or absence of severe anemia (0-1)

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