How is the International Prognostic Scoring System (IPSS) calculated for myelodysplastic syndrome (MDS)?

Updated: Jul 24, 2018
  • Author: Emmanuel C Besa, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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The IPSS has been the most widely used prognostic scoring system for MDS. First published in 1997, it was intended for use with the French-American-British (FAB) classification system which has since been largely supplanted by the World Health Organization (WHO) classification system. The following three factors are rated [17] :

  • The percentage of blasts in the bone marrow (scored on a scale from zero to 2)
  • Karyotype (scored from zero to 1)
  • Cytopenias (scored as zero or 0.5)

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