Which prognostic scoring systems are commonly used for myelodysplastic syndrome (MDS)?

Updated: Jul 24, 2018
  • Author: Emmanuel C Besa, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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The following prognostic scoring systems are most commonly used:

  • International Prognostic Scoring System (IPSS and IPSS-R)
  • WHO Prognostic Scoring System (WPSS)
  • Lower-Risk Prognostic Scoring System (LR-PSS)

NCCN guidelines prefer the IPSS-R over the IPSS or WPSS, and find its predictive power to be comparable to LR-PSS. [24]  The 2014 European Society of Medical Oncology (ESMO) guidelines also recommend IPSS-R while noting that gene mutation profiling (ie, TP53, EZH2, ETV6, RUNX1, ASXL1) may also improve risk stratification but data are still lacking to recommend its use in routine practice. [39]  In contrast, the 2013 European LeukemiaNet (ELN) guidelines recommends that all patients be risk stratified using IPSS. [40]

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