Which organizations have issued guidelines for the diagnosis and management of myelodysplastic syndrome (MDS)?

Updated: Jul 24, 2018
  • Author: Emmanuel C Besa, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

In 2016, the World Health Organization (WHO) released a revision to its 2008 classification scheme for myelodysplastic syndrome (MDS). [38, 16]  The National Comprehensive Cancer Network  (NCCN) has included the revised WHO classificaton system in its 2017 updated guidelines. [24]

The two systems are compared in the table below.

Table. 2008 and 2016 World Health Organization (WHO) classifications of myelodysplastic syndromes (Open Table in a new window)

2008 WHO Classification [16] 2016 WHO Classification [38]
Refractory cytopenia with unilineage dysplasia (RCUD) encompassing refractory anemia (RA), refractory neutropenia (RN), and refractory thrombocytopenia (RT) MDS with single lineage dysplasia (MDS-SLD)
Refractory cytopenia with multilineage dysplasia (RCMD) MDS with multilineage dysplasia (MDS-MLD)
Refractory anemia with ringed sideroblasts (RARS)

MDS with ring sideroblasts (MDS-RS)

       MDS-RS with single lineage dysplasia (MDS-RS-SLD)
       MDS-RS with multilineage dysplasia (MDS-RS-MLD)                                                                                                                                               
Myelodysplastic syndrome associated with isolated del(5q)      MDS with isolated del(5q)
  MDS with excess blasts (MDS-EB)
Refractory anemia with excess blasts–1 (RAEB-1)      MDS-EB-1
Refractory anemia with excess blasts–2 (RAEB-2)      MDS-EB-2
Myelodysplastic syndrome, unclassified (MDS-U) MDS, unclassifiable (MDS-U)
       with 1% blood blasts
       with single lineage dysplasia and pancytopenia
       based on defining cytogenetic abnormality
Refractory cytopenia of childhood Refractory cytopenia of childhood

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