What are the 3-year overall survival rates after hematopoietic stem cell transplantation (HSCT) for myelodysplastic syndrome (MDS)?

Updated: Jul 24, 2018
  • Author: Emmanuel C Besa, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

Increasing score proved predictive of increased relapse (P < 0.001) and treatment-related mortality (P < 0.001) in HLA-matched patients and predictive of relapse (P < 0.001) in the HLA-mismatched cohort. The 3-year overall survival rates after transplantation, by point score, were as follows:

  • Low (0-1 point): 71% (95% confidence index [CI], 58-85%)
  • Intermediate (2-3 points): 49% (95% CI, 42-56%)
  • High (4-5 points): 41% (95% CI, 31-51%)
  • Very high (≥6 points): 25% (95% CI, 4-46%)

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