What is included in the workup of possible myelodysplastic syndrome (MDS)?

Updated: Jul 24, 2018
  • Author: Emmanuel C Besa, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

The workup in patients with possible myelodysplastic syndrome (MDS) includes a complete blood count with differential, peripheral blood smear, and bone marrow studies with cytogenetic studies. In addition to genetic testing for acquired mutations in genes associated with MDS, additional molecular and genetic testing for hereditary hematologic malignancy predisposition may be considered in some patients, particularly in younger ones. [24]

Findings on these studies are used to stage the disease. Because MDS has heterogeneous clinical manifestations and varying clinical outcomes, staging is necessary to determine prognosis and guide the approach to therapy.


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