How is the Myelodysplastic Syndrome International Prognostic Score for myelodysplastic syndrome (MDS) calculated?

Updated: Jul 24, 2018
  • Author: Emmanuel C Besa, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Answer

To improve prognostic classification, the MDS Risk Analysis Workshop developed the Myelodysplastic Syndrome International Prognostic Scoring System (IPSS). The IPSS was published in 1997 and updated in 2012. [17, 18] The revised IPPS (IPSS-R)  score is calculated on the basis of five variables:

  • Hemoglobin level

  • Absolute neutrophil count

  • Platelet count

  • Percentage of bone marrow blasts

  • Cytogenetic category


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