What is the role of clonal mutations in the pathogenesis of myelodysplastic syndrome (MDS)?

Updated: Jul 24, 2018
  • Author: Emmanuel C Besa, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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MDS develops when a clonal mutation predominates in the bone marrow, suppressing healthy stem cells. The clonal mutation may result from genetic predisposition or from hematopoietic stem cell injury caused by exposure to any of the following:

  • Cytotoxic chemotherapy
  • Radiation
  • Viral infection
  • Genotoxic chemicals (eg, benzene)

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