What is included in the long-term monitoring of solitary plasmacytoma?

Updated: Dec 31, 2019
  • Author: Suzanne R Fanning, DO; Chief Editor: Emmanuel C Besa, MD  more...
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Periodic evaluation for progression and development of multiple myeloma is recommended every 6 weeks for the first 6 months for solitary bone plasmacytoma (SBP) and extramedullary plasmacytoma (EMP), with extension of clinic appointments thereafter. Besides a complete history and physical examination, the following tests are recommended:

  • Complete blood cell (CBC) count

  • Complete metabolic panel with lactic dehydrogenase (LDH), calcium, phosphorus, C-reactive protein (CRP), and beta2 microglobulin

  • Erythrocyte sedimentation rate (ESR)

  • Serum protein electrophoresis with immunofixation

  • Serum immunoglobulin quantification

  • Urinary protein electrophoresis with immunofixation (24-h urine sample)

  • Skeletal bone survey

Orthopedic follow-up is recommended for solitary bone plasmacytoma (SBP) and/or ear-nose-throat follow-up is recommended extramedullary plasmacytoma (EMP), based on the tumor location.

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