Which histologic findings are characteristic of solitary plasmacytoma?

Updated: Dec 31, 2019
  • Author: Suzanne R Fanning, DO; Chief Editor: Emmanuel C Besa, MD  more...
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For solitary bone plasmacytoma (SBP), biopsy of the lesion reveals infiltration of the bone by monoclonal plasma cells.

In extramedullary plasmacytoma (EMP), the soft-tissue lesion commonly exhibits submucosal growth; depending on the tumor location, it may require deep biopsy, open biopsy, or complete excision. [14]  The final diagnosis of EMP is made through histological and immunohistochemical features, which demonstrate that the tumor is composed of neoplastic monoclonal plasma cells intensely positive for CD138 and show kappa light chain restriction. [11]  Histologically, EMPs are classified as low, intermediate, or high grade. [23]  Bone marrow biopsy shows less than 5% plasma cells without evidence of clonality. [12]

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