Which physical findings are characteristic of solitary bone plasmacytoma (SBP)?

Updated: Mar 10, 2021
  • Author: Suzanne R Fanning, DO; Chief Editor: Emmanuel C Besa, MD  more...
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Solitary bone plasmacytoma (SBP) may involve any bone, but it has a predisposition for the red marrow–containing axial skeleton. Spinal disease is observed in 34-72% of cases. The thoracic vertebrae are most commonly involved, followed by the lumbar, sacral, and cervical vertebrae. [10]  The rib, sternum, clavicle, or scapula is involved in 20% of cases. [28]  Physical findings are related to the site of involvement, patients may present with a painful mass, pathologic fracture (in those with long bone involvement [10] ), or root or spinal cord compression syndrome.

Occasionally, patients with SBP may present with peripheral polyneuropathy, [29, 30]  or with features that are consistent with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes). [31]

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