Which clinical history findings are characteristic of extramedullary plasmacytoma (EMP)?

Updated: Mar 10, 2021
  • Author: Suzanne R Fanning, DO; Chief Editor: Emmanuel C Besa, MD  more...
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Extramedullary plasmacytoma (EMP) presents as a mass growing in the aerodigestive tract in 80-90% of patients, often with spread to lymph nodes, although other sites are affected as well. Common complaints include the following [13, 25, 26, 27] :

  • Headache
  • Nasal discharge
  • Epistaxis
  • Nasal obstruction
  • Sore throat
  • Hoarseness
  • Dysphonia
  • Dysphagia
  • Dyspnea
  • Epigastric pain
  • Hemoptysis

Gastrointestinal EMPs can present as loss of appetite, bleeding, and abdominal discomfort or obstruction. [11]  

Symptoms from EMP in other tissues are associated with the site of the tumor, tumor size, and compression and/or involvement of the surrounding structures.

EMP involving the lung most commonly presents as a pulmonary nodule or hilar mass.

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