What is the prognosis of extramedullary plasmacytoma (EMP)?

Updated: Mar 10, 2021
  • Author: Suzanne R Fanning, DO; Chief Editor: Emmanuel C Besa, MD  more...
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Patients with EMP have a 5-year survival rate of about 82% and 10-year disease-specific survival rate greater than 50%. [11]  The rate of progression to multiple myeloma is lower than in SBP, ranging from 11% to 30% at 10 years. [14]  Patients with EMP that progressed to multiple myeloma had a 5-year survival rate of 100%, compared with 33% for those with SBP. [23]  In a review of 721 cases by Alexiou and colleagues, after treatment, approximately 65% of patients were free of recurrence and did not progress to multiple myeloma, 22% experienced recurrence, and 15% of cases evolved to multiple myeloma. [15]

In one study, local control following radiation therapy was achieved in 83% of patients with low-grade histology versus 17% of patients with intermediate- to high-grade tumors. [24]

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