What is the prevalence of solitary plasmacytoma?

Updated: Mar 10, 2021
  • Author: Suzanne R Fanning, DO; Chief Editor: Emmanuel C Besa, MD  more...
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Solitary plasmacytoma (SP) has an annual incidence of less than 450 cases in the United States. [2]  Solitary bone plasmacytoma (SBP) affects fewer than 5% of patients with plasma cell disorders. [10, 7] Extramedullary plasmacytoma (EMP) represents approximately 3% of all plasma cell neoplasms. [11] In the United States during 2003‐2016, overall incidence rates in adults were 0.45 per 100,000 persons for SP and 0.09 per 100,000 persons for extramedullary plasmacytoma. [12]

Population studies have reported a male predominance in the SP with a male-to-female ratio of 1.6:1. In studies focusing primarily on SBP, the male-to-female ratio ranges from 1.5–2.4:1. Among EMP patients, a 3:1 male predominance has been reported in sites involving upper airway tract. [2]

SP primarily affects adults over 40 years old, and its incidence increases with age. [2]  The median age of patients with either SBP or EMP is 55 years. This median age is 10 years younger than in patients with multiple myeloma. [13, 3, 14, 15, 16]

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