Which chemistry tests are indicated in the workup of Waldenström macroglobulinemia?

Updated: May 29, 2020
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Chemistry tests include the following [25] :

  • Lactate dehydrogenase (LDH) levels - May be elevated, indicating the extent of Waldenström macroglobulinemia–related tissue involvement

  • Uric acid levels - May be elevated

  • Erythrocyte sedimentation rate (ESR) - May be elevated

  • Renal and hepatic function

  • Total protein levels

  • Albumin-to-globulin ratio

  • Creatinine - Occasionally elevated

  • Electrolytes - Occasionally abnormal; hypercalcemia is noted in approximately 4% of patients; hyponatremia may be present

  • Rheumatoid factor, cryoglobulins, direct antiglobulin test, and cold agglutinin titer results - May be positive

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