Which medications in the drug class Coagulation Factors are used in the treatment of von Willebrand Disease?

Updated: Dec 30, 2019
  • Author: Eleanor S Pollak, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Coagulation Factors

Replacing coagulation factors are essential to successfully managing bleeding episodes.

von Willebrand factor, recombinant (Vonvendi)

Recombinant von Willebrand factor that promotes platelet aggregation and platelet adhesion on damaged vascular endothelium. It is indicated for on-demand treatment and control of bleeding episodes in adults aged 18 years or older with von Willebrand disease.

Antihemophilic factor/von Willebrand factor complex (Alphanate, Humate P, Wilate)

When DDAVP cannot raise the vWF level to hemostatically acceptable levels, a blood product containing vWF may be required. VWF, a protein found in normal plasma, is necessary for clot formation; when administered, it can temporarily correct coagulation defects of patients with classic hemophilia (hemophilia A), in whom a deficiency of FVIII exists. The specific activity of different brand products varies. Humate-P and Alphanate are products containing both FVIII and vWF. The dose depends on the patient's weight, the severity of hemorrhage, the severity of deficiency, the presence of inhibitors, and the desired FVIII level.

The clinical effect on the patient is the most important determinant of therapy. When inhibitors are present, dose requirements are extremely variable and are determined by clinical response. The length of treatment and the loading dose depend on the extent and location of the hemorrhage.

Alphanate is indicated for the prevention of excessive bleeding for surgical and/or invasive procedures in vWD when desmopressin is either ineffective or contraindicated. It is not indicated for patients with severe vWD (ie, type III) who are undergoing major surgery.

Humate-P is indicated for the treatment and prevention of spontaneous and trauma-induced bleeding episodes for patients with mild to moderate or severe vWD.


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