Which medications in the drug class Antifibrinolytic Agents are used in the treatment of von Willebrand Disease?

Updated: Dec 30, 2019
  • Author: Eleanor S Pollak, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Antifibrinolytic Agents

Antifibrinolytics may be used to prevent the breakdown of formed blood clots in order to temper hemorrhage. These agents block the formation of plasmin. They may be used to manage mucosal bleeding, particularly in the nasopharynx and in the gastrointestinal and genitourinary tracts. Antifibrinolytics are most often used concomitantly with other medications for dental extractions and oral surgery.

Aminocaproic acid (Amicar)

Aminocaproic acid inhibits fibrinolysis via the inhibition of plasminogen activator substances and, to a lesser degree, through antiplasmin activity. Its main disadvantage is that thrombi that form during treatment are not lysed, and its effectiveness is uncertain. Aminocaproic acid has been used to prevent the recurrence of subarachnoid hemorrhage.

Tranexamic acid (Cyklokapron, Lysteda)

Tranexamic acid is an alternative to aminocaproic acid. It inhibits fibrinolysis by displacing plasminogen from fibrin.


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