What are the regimens for desmopressin (DDAVP) for the treatment of von Willebrand disease (vWD) type 1?

Updated: Dec 30, 2019
  • Author: Eleanor S Pollak, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

DDAVP regimens are not standardized. A review by Neff notes the following [28] :

  • Dosing DDAVP at 24 hour intervals may reduce the risk of side effects without significantly compromising vWF activity/FVIII:C levels; most treatment centers will not prescribe more than three doses at this frequency
  • Standard intravenous and subcutaneous DDAVP doses are 0.3 µg/kg, but for patients over 50 kg, a fixed dose of 15 µg may provide acceptable efficacy with less risk of serious side effects

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