What are the treatment options for von Willebrand disease (vWD)?

Updated: Dec 30, 2019
  • Author: Eleanor S Pollak, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

The main treatment options for patients with von Willebrand disease (vWD) are as follows:

  • Desmopressin (DDAVP) - DDAVP is a synthetic analogue of the antidiuretic hormone vasopressin; it has enhanced antidiuretic activity and no pressor activity related to vasopressin. 
  • Recombinant von Willebrand factor (rVWF) - Indicated for on-demand treatment of minor or major hemorrhage in adults with vWD [24]
  • Von Willebrand factor/factor VIII (vWF/FVIII) concentrates.  Purified plasma-derived concentrates of vWF/FVIII are used for treatment of bleeds and for surgical prophylaxis when DDAVP is ineffective or contraindicated. [3, 13]

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