How is von Willebrand disease (vWD) type 3 diagnosed?

Updated: Dec 30, 2019
  • Author: Eleanor S Pollak, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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This is a recessive disorder in which vWF protein is virtually undetectable. The absence of vWF causes a secondary deficiency of FVIII and a subsequent severe combined defect in blood clotting and platelet adhesion. Results from screening assays show both absent or severely decreased RCoF activity and vWF:Ag in addition to a prolonged aPTT.

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