How is von Willebrand disease (vWD) type 2B diagnosed?

Updated: Dec 30, 2019
  • Author: Eleanor S Pollak, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

In type 2B, brisk platelet agglutination occurs at low concentrations of ristocetin that have little or no effect on platelet-rich plasma from normal controls. Similar results are seen in one extremely rare disease, platelet-type vWD. In platelet-type vWD, mutations in platelet GpIb cause a phenotype similar to that of vWD type IIB.


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