How is von Willebrand disease (vWD) type 2A diagnosed?

Updated: Dec 30, 2019
  • Author: Eleanor S Pollak, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Disproportionately low RCoF activity relative to vWF:Ag may reflect a decreased affinity of vWF for platelets. The most common cause of such loss of function is the absence of hemostatically effective large vWF multimers, characteristic of vWD type 2A. This subtype is diagnosed based on the combination of markedly reduced RCoF activity and compatible multimer gel analysis results.


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