Which lab tests are used to screen for von Willebrand disease (vWD)?

Updated: Dec 30, 2019
  • Author: Eleanor S Pollak, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Screening tests typically include the following:

  • Prothrombin time (PT)
  • Activated partial thromboplastin time (aPTT)
  • Factor VIII (FVIII) coagulant activity
  • Ristocetin cofactor (RCoF) activity
  • Concentration of vWF antigen (vWF:Ag)

Additional testing to confirm the specific subtype may include the following [20] :

  • VWF collagen-binding activity
  • Low-dose ristocetin vWF-platelet binding
  • FVIII-VWF binding
  • VWF multimer analysis
  • VWF propeptide antigen

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