What is the role of lab studies in the diagnosis of von Willebrand disease (vWD)?

Updated: Dec 30, 2019
  • Author: Eleanor S Pollak, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Laboratory studies are directed towards documenting a deficiency of von Willebrand factor (vWF). [13, 14]  Levels of vWF vary with physiologic stress; in particular, plasma levels increase with estrogens, vasopressin, growth hormone, and adrenergic stimuli. Thus, vWF levels may intermittently be normal in patients with von Willebrand disease (vWD), and measurements should be repeated to confirm abnormal results.


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