What are the most common signs and symptoms of von Willebrand disease (vWD)?

Updated: Dec 30, 2019
  • Author: Eleanor S Pollak, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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The most common signs of von Willebrand disease (vWD) include nosebleeds and hematomas. Prolonged bleeding from trivial wounds, oral cavity bleeding, and excessive menstrual bleeding are common. Gastrointestinal bleeding rarely occurs. Other manifestations include the following [13, 14] :

  • Easy bruising - Common but nonspecific

  • Prolonged bleeding - After minor trauma to skin or mucous membranes

  • Severe hemorrhage - After major surgery; less common

  • Delayed bleeding - May occur up to several weeks after surgery

  • Heavy bleeding - Common after tooth extraction or other oral surgery, such as tonsillectomy and adenoidectomy

  • Menorrhagia - Common presenting complaint in women

  • Exacerbation of bleeding symptoms - After ingestion of aspirin

  • Amelioration of bleeding symptoms with use of oral contraceptives

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